Then C, Herder C, Thorand B, et al. - Findings demonstrate inverse association of serum uromodulin with chemerin and retinol-binding protein-4 (predominantly pro-inflammatory adipokines).

• In 795–1,080 participants of the KORA F4 study aged 62–81 years, the association of serum uromodulin with adipokines was examined and the effect modification by diabetes status was evaluated.

• Serum uromodulin was found to be inversely related to chemerin and retinol-binding protein-4 following multivariable adjustment and Bonferroni correction for multiple testing.

• The associations were stronger in patients with type 2 diabetes than those without diabetes.

• However, the link of serum uromodulin with type 2 diabetes was shown to be independent of chemerin and retinol-binding protein-4.

• No significant link was found between uromodulin and the other adipokines (leptin, adiponectin, secreted frizzled-related protein 5, progranulin, omentin-1 and vaspin) post-correcting for multiple testing.