Rosenbohm A, et al. - This study entailed an analysis of the tie-up between the onset and prognosis of amyotrophic lateral sclerosis (ALS) and serum retinol-binding protein 4 (RBP4) concentration as a biomarker for insulin resistance and vitamin A metabolism. An inverse connection was brought to light between RBP4 with the risk for and prognosis of ALS. This data pointed out the possible involvement of vitamin A metabolism or impaired insulin signaling.