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Association of serum proprotein convertase subtilisin/kexin type 9 with early atherosclerosis in newly diagnosed type 2 diabetes mellitus

Nutrition, Metabolism & Cardiovascular Diseases Apr 30, 2019

Guo W, et al. - Among 100 newly diagnosed type 2 diabetes mellitus (T2DM) cases, researchers examined the link between serum proprotein convertase subtilisin/kexin type 9 (PCSK9) levels and early atherosclerosis as evaluated by carotid intimal-medial thickness (CIMT) and brachial-ankle pulse wave velocity (ba-PWV). Measurements of serum PCSK9 levels, CIMT, ba-PWV, and metabolic parameters were obtained. Findings revealed a significant correlation of serum PCSK9 levels with CIMT and ba-PWV, independent of CAD risk factors. Serum PCSK9 level, thus, might be a prescriptive biomarker for early arteriosclerosis in such cases.

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