Xuan Y, et al. - Since oxidative stress plays an important role in the pathophysiology of type 2 diabetes mellitus (T2DM), researchers evaluated the associations with incident major cardiovascular events (MCE), cancer incidence, and all-cause mortality using multivariable adjusted Cox proportional hazards models with time-dependent modeled derivatives of reactive oxygen metabolites levels and total thiol levels. In total, during 6–7 years of follow-up, 205, 179, and 394 MCE, cancer, and all-cause mortality cases were noted. The observed powerful associations of both biomarkers with mortality indicate a significant contribution to the premature mortality of diabetes patients from an imbalanced redox system. No cancer associations have been identified.