Ruiz VH, Edjolo A, Roubaud-Baudron C, et al. - In this prospective, 6-year follow-up cohort study, researchers explored the connection between seropositivity to Borrelia burgdorferi (Bb) and incidental neuropsychiatric disorders (eg, cognitive decline, incident dementia, and depressive symptoms) as well as functional decline. This investigation was carried out in a rural southwestern region of France. The sample consisted of 689 retired farmers 65 years or older randomly recruited from the Farmer Health Insurance System who agreed to submit a blood sample and were members in the Aging Multidisciplinary Investigation study, an ongoing epidemiological prospective study of aging initiated in 2007. Data reported that the seroprevalence rate of Bb was 6.5%. No significant connection was found between seropositivity for Bb and any of the studied outcomes (ie, cognitive decline, incident dementia, depressive symptoms, and functional decline). Bb exposure is a compulsory risk factor for developing or clinically manifested Lyme borreliosis. Previous exposure to the causative agent of Lyme borreliosis "alone" (seropositivity) is not sufficient as a risk factor for incidental neuropsychiatric outcomes, like cognitive decline, dementia, depression, and even disability in older adults residing in rural areas in the southwestern region of France.