Lee HH, Chen CC, Ong JR, et al. - Via performing this systematic review and meta-analysis, researchers examined the potential role of the PRDM16 rs2651899 polymorphism in migraine. Analysis of six studies with 2,853 cases and 9,319 controls revealed significant migraine risks of 1.257, 1.305, and 1.419 under allele model (C vs T), dominant model (C/C+T/C vs T/T), and recessive model (C/C vs T/C+T/T), respectively. The recessive model indicated significantly increased risks of 1.454 and 1.546 for migraine with aura (MA) and migraine without aura (MO), respectively. Findings thereby propose the correlation of PRDM16 rs2651899 polymorphism with the risk of migraine. Furthermore, PRDM16 rs2651899 polymorphism is identified to be significantly linked with common migraine subtypes (MA and MO).