Lee HH, Chen CC, Ong JR, et al. - Via performing this systematic review and meta-analysis, researchers sought to examine the role of the PRDM16 rs2651899 polymorphism in migraine. Searching the PubMed, Embase, and Google Scholar databases, they included six studies with 2,853 cases and 9,319 controls in this meta-analysis. Findings revealed overall, significant migraine risks of 1.257, under allele model (C vs T), 1.305 under the dominant model (C/C+T/C vs T/T), and 1.419 under recessive model (C/C vs T/C+T/T), respectively. They identified significantly heightened risks of 1.454 and 1.546 for migraine with aura (MA) and migraine without aura (MO), respectively, in the recessive model. Findings thereby suggest the existence of an association of PRDM16 rs2651899 polymorphism with the risk of migraine. Moreover, PRDM16 rs2651899 polymorphism seems to be significantly related to common migraine subtypes (MA and MO).