Fu Y, et al. - Researchers gauged the relationship between psoriasis and inflammatory bowel disease (IBD). Results demonstrated a significant association of psoriasis with IBD. When patients with psoriasis present with bowel symptoms, a gastroenterology consultation is suggested.

Methods

• Researchers conducted a systematic review and meta-analysis and searched MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials for relevant studies from inception to January 17, 2018.
• They included the case-control, cross-sectional, or cohort studies that examined either the odds or risk of IBD in patients with psoriasis.
• They did not use any geographic or language limitations in the search and they followed PRISMA and MOOSE guidelines for data extraction.
• In order to assess the risk of bias of included studies, the Newcastle-Ottawa Scale was used; they separately analyzed Crohn disease and ulcerative colitis and conducted random-effects model meta-analysis and a subgroup analysis on psoriatic arthritis.
• Main outcomes and measures included the risk and odds of IBD, Crohn disease, and ulcerative colitis in patients with psoriasis.

Results

• As per data, they included a total of 5 case-control or cross-sectional studies and 4 cohort studies with 7,794,087 study participants.
• Psoriasis and Crohn disease (odds ratio, 1.70; 95% CI, 1.20-2.40) and psoriasis and ulcerative colitis (odds ratio, 1.75; 95% CI, 1.49-2.05) were significantly associated.
• An increased risk of Crohn disease (risk ratio, 2.53; 95% CI, 1.65-3.89) and ulcerative colitis (risk ratio, 1.71; 95% CI, 1.55-1.89) was seen in the patients with psoriasis.