Shinall M, Arya S, Youk A et al. - This retrospective cohort study was designed to evaluate the correlation between frailty and mortality at varying levels of operative stress as measured by the Operative Stress Score, a novel measure created for this study. They enrolled a total of 432,828 unique individuals in the Veterans Administration Surgical Quality Improvement Program between April 1, 2010, and March 31, 2014, who underwent a noncardiac surgical procedure at Veterans Health Administration Hospitals and had information available on vital status at 1 year postoperatively. A novel operative stress score was developed to quantify physiologic stress for surgical procedures. High rates of postoperative mortality were noted in individuals who were frail and very frail across all levels of the Operative Stress Score. These outcomes imply that frailty screening should be used universally because low- and moderate-stress procedures may be high risk among patients who are frail.