Baker BH, Lugo-Candelas C, Wu H, et al. - In this birth cohort study involving 345 children (177 boys [51.3%]; mean [SD] age, 6.58 [0.54] years), researchers investigated the relationship between prenatal acetaminophen exposure measured in meconium (hereinafter referred to as meconium acetaminophen) and attention-deficit/hyperactivity disorder (ADHD) in children aged 6 to 7 years, along with the potential for mediation by functional brain connectivity. According to findings, acetaminophen exposure detected in meconium was linked to increased chances of ADHD and altered brain connectivity between the frontoparietal and default mode networks to sensorimotor cortices. The correlation of prenatal acetaminophen exposure with hyperactivity was mediated by altered frontoparietal-sensorimotor cortex connectivity. The results that ADHD and related brain phenotypes are associated with exposure to prenatal acetaminophen measured directly in meconium suggest that the safety of the medication should be reassessed throughout pregnancy.