Association of pregnancy with the onset of clinically isolated syndrome
JAMA Sep 18, 2020
Nguyen AL, Vodehnalova K, Kalincik T, et al. - Women are diagnosed with multiple sclerosis (MS) usually during their childbearing years. Researchers here examined if pregnancy can delay the first episode of demyelination or clinically isolated syndrome (CIS). In this multicenter cohort study, 2,557 women with CIS were assessed for their reproductive history (duration of each pregnancy, date of delivery, length of breastfeeding). Analyses revealed a later onset of CIS among women with previous pregnancies and childbirths vs without. They suggested no correlation of a higher number of pregnancies and childbirths with later CIS
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