Yuan Y, et al. – This study suggests that the pro-inflammatory (interleukin (IL)-6, C-reactive protein (CRP)) and coagulation factors (D-dimer) serve as biomarkers of aging. Experts aspire to find out if these biomarkers are associated with reduced relative dose intensity (RDI) in women with stage I–III breast cancer (BC). Findings shed light on the association between increased pre–chemotherapy biomarkers of aging (IL–6 and D–dimer) and reduced RDI (<85%).