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Association of postoperative influenza vaccine on overall mortality in patients undergoing curative surgery for solid tumors

International Journal of Cancer Nov 02, 2020

Gögenur M, Fransgård T, Krause TG, et al. - In view of recent findings suggesting modification of the immune system in favor of antitumor cytotoxicity by the influenza vaccine, researchers here examined if an influenza vaccine received in the postoperative period reduces overall and cancer‐specific mortality in patients undergoing curative surgery for solid cancers. In this registry‐based national observational study conducted in Denmark, they included patients with solid cancers undergoing curative surgery with a follow‐up period of 3 years starting from 180 days after surgery. Among a total of 21,462 included patients, there were 2,557 patients who received an influenza vaccine within 6 months after surgery. In a Cox regression model, patients given a vaccine vs those never receiving a vaccine exhibited a reduction in overall mortality and cancer‐related mortality. They identified a reduction in overall mortality and cancer‐specific mortality in a predefined subgroup of patients receiving a vaccine within 30 days after surgery. Patients receiving the vaccine after 30 days to 6 months after surgery did not exhibit the association.

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