McIsaac DI, et al. - Researchers investigated the association of polypharmacy with survival, complications, and resource use among older patients undergoing elective surgery in Ontario, Canada, between 2002 and 2014. Multilevel, multivariable adjustment for demographics, comorbidities, previous healthcare use, and surgical factors was followed by estimation of the associations of polypharmacy with 90-day survival, complications, length of stay, costs, discharge location, and readmissions. They also conducted prespecified and post hoc sensitivity analyses. In perioperative population, a high-risk was found in older patients with polypharmacy. However, the causality and generalizability of the polypharmacy-adverse outcome link that was well documented in nonsurgical patients, was called into question by the findings.