Qu Y, et al. - In a Chinese population, researchers assessed the risk of esophageal squamous cell carcinoma (ESCC) in relation to polymorphisms in long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1). For four tag single nucleotide polymorphisms (SNPs) of MALAT1, ie, rs3200401 C > T, rs1122709 C > G, rs664589 C > G, and rs619586 A > G, genotyping was performed in 245 ESCC patients and 490 gender- and age-matched cancer-free controls. In order to determine the link between the tag SNPs and risk of ESCC, they carried out statistical analyses including chi-squared test and logistic regression. To adjust for multiple comparisons, they applied false discovery rate (FDR) <25%. An increased risk of ESCC was reported in relation to polymorphism rs3200401 C > T in MALAT1 gene. A minor possibility that rs619586 A > G might be a protective factor for ESCC was suggested as following FDR adjustment, the link between rs619586 A > G polymorphism and ESCC risk was not significant.