Mitra S, et al. - During this study, authors intended to investigate the relative likelihood of hemodynamically significant patent ductus arteriosus (PDA) closure with common pharmacotherapeutic interventions as well as sought to compare the adverse event rates in preterm infants with a gestational age younger than 37 weeks treated with intravenous or oral indomethacin, ibuprofen, or acetaminophen vs each other, placebo, or no treatment for a clinically or echocardiographically diagnosed hemodynamically significant PDA. Findings shed light on the correlation between a high dose of oral ibuprofen with a higher likelihood of hemodynamically significant PDA closure compared to standard doses of intravenous ibuprofen or intravenous indomethacin. Additionally, it was deduced that placebo or no treatment did not markedly alter the likelihood of mortality, necrotizing enterocolitis, or intraventricular hemorrhage.