Yoon SY, Suh JH, Yang SN, et al. - In Parkinson disease (PD), presence of a dose-response association between physical activity (PA) and all-cause mortality is revealed; although reverse causality might exist. To achieve mortality reduction in PD, modifications to increase and maintain physical activity may be helpful.

• This is a nationwide population-based cohort study including 10,699 individuals with PD.

• Self-reported questionnaires were used to determine physical activity levels.

• Participants who were physically active exhibited lower mortality rate at all PA intensities, vs inactive ones (vigorous: hazard ratio [HR], 0.80; moderate: HR, 0.66; light: HR, 0.81).

• A significant inverse dose-response link was identified between the total amount of PA and mortality (HRs: vigorous, 0.80; moderate, 0.66; light, 0.81).

• Mortality risk was the lowest among participants who performed physical activity before and after the PD diagnosis (HRs: vigorous, 0.66; moderate, 0.49; light, 0.76).

• A lower mortality rate was observed in participants who initiated PA post-PD diagnosis vs those who remained physically inactive (HRs: vigorous, 0.82; moderate, 0.69; light, 0.86).