Batchelor R, Liu DH, Bloom J, et al. - To ascertain how periprocedural intravenous morphine administration could influence clinical results among patients receiving primary percutaneous coronary intervention (PCI) for ST‐elevation myocardial infarction (STEMI), this systematic review and meta‐analysis was performed. Electronic databases of MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), Scopus, Web of Science and ClinicalTrials.gov were searched to identify studies that assessed the link of peri‐PCI intravenous morphine administration with in‐hospital or 30‐day myocardial infarction (primary outcome) as well as in‐hospital or 30‐day mortality. A meta‐analysis was performed including five studies with 3,748 patients. Findings revealed that periprocedural intravenous morphine use was not related to adverse short‐term clinical results among patients receiving primary PCI for STEMI.