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Association of penicillin or cephalosporin allergy documentation and antibiotic use in hospitalized patients with pneumonia

The Journal of Allergy and Clinical Immunology: In Practice May 28, 2021

Mancini CM, Wimmer M, Schulz LT, et al. - Researchers undertook this national cross-sectional analysis to assess the link of a documented penicillin and/or cephalosporin (P/C) allergy to antibiotic use for the management of inpatient pneumonia. There was a documented P/C allergy in 450 (20%) of 2,276 inpatients taking antibiotics for pneumonia at 95 US hospitals. Findings revealed that less probability to receive recommended beta-lactams as well as more chance of receiving carbapenems and fluoroquinolones were observed among inpatients with documented P/C allergy and pneumonia. Improved optimal antibiotic therapy for the 20% of inpatients with pneumonia and a documented P/C allergy may be achieved via inpatient allergy evaluation.

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