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Association of obesity with cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease: Insights from TECOS

American Heart Journal Oct 26, 2019

Pagidipati NJ, Zheng Y, Green JB, et al. - Researchers examined TECOS participants with type 2 diabetes (T2D) and atherosclerotic cardiovascular disease (ASCVD) to determine the link between BMI and ASCVD outcomes in these patient population. They defined BMI groups as underweight/normal weight (BMI < 25 kg/m2), overweight (25–29.9 kg/m2), obese class I (30–34.9 kg/m2), obese class II (35–39.9 kg/m2), and obese class III (≥ 40 kg/m2). The presence of overweight or obesity was found in the majority of TECOS participants with ASCVD and T2D, yet a lower CV risk was observed in overweight or obese class I people vs those who were under/normal weight. Findings supported the obesity paradox, but this paradox may be indicative of an epidemiological artifact instead of a true negative link between normal weight and clinical results.

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