Minneci PC, Hade EM, Lawrence AE, et al. - In this nonrandomized controlled intervention study, which used propensity score weighting and included 1,068 children (median age, 12.4 years; 38% girls), researchers sought to determine the success rate of nonoperative management and to compare differences in treatment-related disability, satisfaction, health-related quality of life, and complications between nonoperative management and surgery in children with uncomplicated appendicitis. For children with uncomplicated appendicitis, an initial nonoperative antibiotic-only treatment approach had a success rate of 67.1% and was correlated with statistically significantly fewer disability days at 1 year compared with urgent surgery. However, there was a substantial follow-up loss, the comparison with the prespecified threshold for an acceptable success rate for nonoperative management was not statistically significant, and the hypothesized disability days difference was not met.