Minneci PC, Hade EM, Lawrence AE, et al. - Researchers conducted this multi-institutional nonrandomized controlled intervention study to analyze the success rate of nonoperative management and to compare variations in treatment-related disability, satisfaction, health-related quality of life, and complications between nonoperative management and surgery in children with uncomplicated appendicitis. The sample consisted of 1,068 children (median age, 12.4 years; 38% girls) aged 7 through 17 years with uncomplicated appendicitis treated at 10 tertiary children’s hospitals across 7 US states between May 2015 and October 2018 with 1-year follow-up through October 2019. For children with uncomplicated appendicitis, an initial nonoperative management strategy with antibiotics alone had a success rate of 67.1% and was correlated with statistically significantly fewer disability days at 1 year compared with urgent surgery. Substantial losses to follow-up, however, were not statistically significant in accordance with the predetermined threshold for an acceptable success rate of nonoperative management, and the estimated gap in disability days was not reached.