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Association of myocarditis with BNT162b2 messenger RNA COVID-19 vaccine in a case series of children

JAMA Aug 15, 2021

Dionne A, Sperotto F, Chamberlain S, et al. - Researchers described a small case series of children diagnosed with myocarditis after COVID-19 vaccination. In this case series, patients exhibited a benign short-term course; however, uncertainty remains concerning the long-term risks.

  • Fifteen children (14 male patients [93%]; median age, 15 years [range, 12-18 years]) were identified who were hospitalized with myocarditis after receipt of the BNT162b2 messenger RNA COVID-19 vaccine for 1 to 5 days.

  • Most frequently males were affected after the second vaccine dose.

  • As per cardiac magnetic resonance imaging, three patients had ventricular systolic dysfunction, and 12 patients had late gadolinium enhancement.

  • No mortality was recorded.

  • Normal echocardiogram results were recorded on follow-up 1 to 13 days after discharge in all except 1 patient.

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