Yanez B, Gray RJ, Sparano JA, et al. - Baseline patient-reported health-related quality of life components like poor social well-being, poor physical well-being, and concomitant depression, were significant risk factors for early termination of endocrine therapy (ET) in this post hoc analysis of a randomized clinical trial. Such findings support the use of systematic screening for patient-reported outcomes and depressive symptoms to identify women who are at risk of ET cessation.

• In total, 954 women (mean [SD] age, 56.6 [8.9] years) were involved in this analysis.

• In a joint model, receipt of chemoendocrine therapy and age older than 40 years were linked to a lower probability of early discontinuation of ET.

• A history of depression compared with no history of depression, worse physical well-being compared with better physical well-being, and worse social well-being compared with better social well-being were all individually and significantly associated with a higher probability of early ET discontinuation when these factors were taken into account.

• Only antidepressant use at the start of the research was linked to early discontinuation.