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Association of maternal SARS-CoV-2 infection in pregnancy with neonatal outcomes

JAMA May 29, 2021

Norman M, Navér L, Söderling J, et al. - Researchers conducted this nationwide, prospective cohort study to assess neonatal outcomes in relation to maternal SARS-CoV-2 test positivity in pregnancy. In total, 2,905 infants (3.2%) were excluded due to malformations. Among 88,159 newborn infants (49.0% girls), 2,323 (1.6%) were delivered by 2,286 SARS-CoV-2–positive mothers. After matching on maternal characteristics, maternal SARS-CoV-2 test positivity was significantly correlated with admission for neonatal care and with neonatal morbidities like respiratory distress syndrome, any neonatal respiratory disorder, and hyperbilirubinemia. Maternal SARS-CoV-2 infection during pregnancy was found to be significantly associated with small increases in some neonatal morbidities in a nationwide cohort of infants in Sweden. The findings should be interpreted as exploratory, given the small number of events for many of the outcomes and a large number of statistical comparisons.

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