Leppert B, Havdahl A, Riglin L, et al. - Via a population-based cohort study of 7,921 mothers, experts examined whether maternal polygenic risk scores (PRSs) for neurodevelopmental disorders were correlated with early-life exposures formerly connected to the disorders. The attention-deficit/hyperactivity disorder PRS was correlated with various prenatal factors, including infections, the use of acetaminophen during late pregnancy, lower blood levels of mercury, and greater blood levels of cadmium. Little proof of correlations between autism spectrum disorder PRS or schizophrenia PRS and prenatal factors were found. There was little relationship between any of the PRSs and adverse birth events seen as well. Sensitivity analyses exhibited constant outcomes. Some pregnancy-related exposures were related to maternal risk alleles for neurodevelopmental disorders, primarily ADHD. Moreover, the necessity of carefully accounting for possible genetic confounding and triangulate evidence from various strategies when evaluating the impacts of prenatal exposures on neurodevelopmental disorders in offspring was suggested.