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Association of low birth weight with altered corneal geometry and axial length in adulthood in the German Gutenberg health study

JAMA Ophthalmology Feb 27, 2019

Fieb A, et al. - A sum of 11,294 eyes of 7120 participants were randomized to assess the relationship of low birth weight in long-term with anterior segment anatomy and axial length in adulthood. Researchers observed an association between lower birth weight and steeper corneal curvature (β=0.005 mm/100 g), smaller white-to-white distance (β=0.006 mm/100 g), thinner central corneal thickness (β=0.327 μm/100 g), and shorter axial length (β=0.006 mm/100 g), after adjustment for age and sex. Although, they did not notice any independent relation between anterior chamber depth and lens thickness and low birth weight in participants with phakia.
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