Xu H, Yang R, Qi X, et al. - Utilizing data from 2,022 participants in the Rush Memory and Aging Project, researchers assessed the link between lifespan cognitive reserve (CR) and dementia risk, taking brain pathologies into account. After exclusions, a total of 1,602 dementia-free older adults were analyzed. From May to September 2018, they analyzed the data. At baseline, information regarding CR factors (education; early-life, midlife, and late-life cognitive activities; and social activities in late life) was collected. Depending on these factors, they captured lifespan CR scores, utilizing a latent variable from a structural equation model and grouped them into tertiles (lowest, middle, and highest). In this study, a reduction in dementia risk was evident in correlation with high lifespan CR, even in the presence of high brain pathologies. The significance of lifespan CR accumulation in dementia prevention was emphasized.