Association of isolated coronary microvascular dysfunction with mortality and major adverse cardiac events: A systematic review and meta‐analysis of aggregate data
Journal of the American Heart Association May 11, 2020
Gdowski MA, Murthy VL, Doering M, et al. - Since there exists a poor understanding of the influence of coronary microvascular dysfunction (CMD), as diagnosed by decreased coronary flow reserve, on the results of patients having symptoms of myocardial ischemia and nonobstructive coronary artery disease, so, researchers analyzed relevant observational studies to examine the link of CMD with outcomes, via a systematic review and meta‐analysis. Online databases were explored to identify the relevant studies. All‐cause mortality was the primary outcome. Findings revealed an approximately 4‐fold rise in mortality as well as a 5‐fold increase in major adverse cardiac events, both, in relation to CMD.
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