Ouldali N, Toubiana J, Antona D, et al. - Researchers conducted the study for comparing the outcomes of children with multisystem inflammatory syndrome in children (MIS-C) associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection treated with intravenous immunoglobulins (IVIG) and methylprednisolone vs IVIG alone. The sample consisted of 111 children (58 females [52%]; median age, 8.6 years [interquartile range, 4.7 to 12.1]) with MIS-C. According to this retrospective cohort study, treatment with IVIG and methylprednisolone vs IVIG alone was linked to a lower risk of treatment failure. Treatment with IVIG and methylprednisolone vs IVIG alone was correlated with a more favorable fever course in children with MIS-C. The interpretation of the study is limited to the observational design.