Ghalandari M, Jamialahmadi K, Nik MM, et al. - Researchers undertook this cross sectional analysis to determine the link of a genetic variant in interleukin-10 (IL-10) with the risk of developing coronary-artery-disease (CAD) and the severity of the disease. They also conducted a systematic review and meta-analysis to further explore. In Iranian population, the cumulative outcomes of the link between IL and 10 –592 C > A polymorphism and CAD were also reported. The Mashhad-Stroke and Heart-Atherosclerotic-Disorders cohort was used to select 948 people including 307 healthy controls and 641 patients. Significantly higher frequency of the variant A allele of the IL-10 –592 C > A was detected in CAD patients vs controls. A significantly higher risk of CAD was observed in persons carrying AA genotype vs those carrying the wild type genotype. Findings showed that genetic polymorphism in the IL10 gene was significantly associated with cardiovascular diseases, but this observation could not be corroborated in meta-analysis. There is a necessity for further functional analysis and assessment of this marker in a multicenter setting in order to establish its worth as a risk stratification marker.