Nasrallah IM, Gaussoin SA, Pomponio R, et al. - In this study, the relationship of intensive blood pressure control on Alzheimer disease (AD)-related brain biomarkers were explored. Researchers designed a substudy of the Systolic Blood Pressure Intervention Trial, a multicenter randomized clinical trial comparing the effectiveness of 2 different blood pressure-lowering strategies. Individuals were assigned randomly to either a systolic blood pressure goal of less than 120 mmHg (intensive treatment: n = 356) or less than 140 mmHg (standard treatment: n = 317). In comparison with standard treatment, intensive treatment was correlated with a small but statistically significantly greater decrease in hippocampal volume, consistent with the observation that intensive treatment is correlated with greater decreases in total brain volume. Nevertheless, compared with standard treatment, intensive treatment was not correlated with changes in any of the other MRI biomarkers of AD.