Murugappan G, Li S, Alvero RJ, et al. - The correlation between female infertility and all-cause mortality was investigated via retrospectively analyzing 72,786 infertile women identified in the Optum Clinformatics Datamart from 2003-2019 by infertility diagnosis, testing and treatment codes and 3,845,790 non-infertile women seeking routine gynecologic care. Among 16,473,458 person-years of follow up, death of 13,934 women was observed. Although the two groups exhibited a low absolute risk of death, infertile women faced a higher relative risk of mortality compared with non-infertile women. The association remained when stratified by age < 35 or ≥35 years or baseline medical comorbidity. Importantly, there was no correlation of infertility treatment with a raised risk of death. Findings herein reinforce the disease burden linked with infertility and its potential for longer-term sequelae.