Chalak LF, Pappas A, Tan S, et al. - In asphyxiated neonates receiving hypothermia therapy, an association was found between higher odds of electrographic seizures during rewarming and death or disability at 2 years. Therefore, electroencephalography monitoring during rewarming is necessary in infants at risk.

• This prespecified nested cohort study included 120 newborns randomized to either 72 hours of cooling (group A) or 120 hours (group B).

• Comparisons of serial amplitude electroencephalography recordings in the 12 hours prior and 12 hours during rewarming was performed.

• During the rewarming epoch, more infants had electrographic seizures vs the preceding epoch (group A, 27% vs 14%; group B, 21% vs 10%).

• For group A, adjusted odd ratios (95% CIs) for seizure frequency during rewarming were 2.7 (1.0-7.5), it was estimated to be 3.2 (0.9-11.6) for group B.

• Post-adjustments, significantly higher was the composite death or moderate to severe disability outcome at 2 years in infants with electrographic seizures during rewarming (relative risk [95% CI], 1.7 [1.25-2.37]).