Zuo Y, Han X, Tian X, et al. - Findings revealed an elevated risk of incident cardiovascular disease (CVD) in association with increasing abnormal fasting plasma glucose (FPG) levels in people without diabetes or other conventional atherosclerotic cardiovascular disease (ASCVD) risk factors. Thus, primordial prevention for FPG level rises along with other traditional ASCVD risk factors is important.

• A total of 38,297 participants (men, 62.1%; mean age, 47.9 [12.9] years) who were free of a history of CVD, absent of ASCVD risk factors, and had a FPG level between 70 to 125 mg/dl at baseline were observed until new-onset CVD event, death or December 31, 2017.

• Occurrence of 1,217 incident CVD events was revealed during a median follow-up of 11.0 years (interquartile range, 10.7-11.2 years).

• Relative to those with FPG 70 to 99 mg/dl, participants with FPG 100 to 109 mg/dl and 110 to 125 mg/dl had 1.18 and 1.27 estimated multivariable adjusted hazard ratios for CVD, respectively.

• A J-shaped link between FPG and CVD risk was demonstrated by multivariable-adjusted spline regression model.