Landgren O, Hofmann JN, McShane CM, et al. - Via a cohort study of 685 people with a diagnosis of progressing or stable monoclonal gammopathy of undetermined significance (MGUS), researchers longitudinally examined the changes of serum immune markers with stable vs progressive MGUS. In cross-sectional modeling, IgA isotype, 15 g/L or more monoclonal spike, skewed serum free light chains ratio, and severe immunoparesis (≥ 2 suppressed uninvolved immunoglobulins) were risk factors related to progressive MGUS whereas skewed serum free light chains ratio and severe immunoparesis were risk factors correlated with progressive light-chain MGUS. In a longitudinal analysis of individuals with serial samples former to progression, 23 of 43 people had high-risk MGUS prior to the progression and 16 of these 23, experienced conversion from low-risk or intermediate-risk MGUS within 5 years. Comparable outcomes were discovered for light-chain MGUS. Thus, for patients with MGUS or light-chain MGUS, the findings of evolving risk patterns recommend annual blood testing and risk evaluation.