Association of IL‐10 gene promoter polymorphisms with food allergy susceptibility and serum IL‐10 level in a pediatric Caucasian population
Pediatric Allergy and Immunology Apr 07, 2021
Nedelkopoulou N, Taparkou A, Raftopoulou S, et al. - Experts aspired to explore whether genetic polymorphisms in the promoter region of the IL‐10 gene are correlated with food allergy (FA) susceptibility in Caucasian pediatric patients with concomitant allergic diseases and IL‐10 levels. The single nucleotide polymorphisms (SNPs) at ‐1082A > G (rs1800896), ‐819 T > C (rs1800871), and ‐592A > C (rs1800872) of 62 pediatric patients with IgE‐mediated FA were investigated and associated with clinical parameters, serum IgE and IL‐10 levels. The outcomes were contrasted with those of 92 healthy controls without FA, personal and/or family history of atopy. Polymorphisms in the promoter region of the IL‐10 gene are not linked to FA susceptibility in the cohort. In FA patients, ‐1082 A/G SNPs appear to influence IL‐10 production, the severity of FA symptoms, and the development of atopic asthma in this population.
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