Fudim M, Hopley CW, Huang Z, et al. - Among 13,885 participants with symptomatic peripheral artery disease in the EUCLID trial (Examining the Use of Ticagrelor in Peripheral Artery Disease), researchers examined whether and how a history of hypertension and office systolic blood pressure (SBP) were related to major adverse cardiovascular events (MACEs) and major adverse limb events (MALEs). A median follow-up of 30 months was performed. To compute hazard ratios for any MACE, MALE, and MALE including lower extremity revascularization, Cox proportional hazards regression was applied. As per findings, no higher hazard for MACE or MALE was observed in relation to a history of hypertension in patients with peripheral artery disease. In contrast, patients with out-of-target low and high SBP were found to have a higher hazard of MACE. In addition, an increased risk of ischemic limb events was observed in relation to high but not low SBP.