Lamprea-Montealegre JA, McClelland RL, Otvos JD, et al. - Across classes of estimated glomerular filtration rate (eGFR), researchers assessed incident cardiovascular disease (CVD) events in relation to high-density lipoprotein particles (HDLp) size, particle subfractions, and apolipoprotein C-III content among 6,699 participants in MESA (Multi-Ethnic Study of Atherosclerosis) with measurements of HDLp and 5,723 participants with measurements of HDL apolipoprotein C-III. They assessed the links between HDLp and apolipoproteins with CVD events by using Cox-regression methods. Findings revealed lower CVD risk in relation to HDL particles of larger size and higher levels of large HDL and of HDL without apolipoprotein C-III, with risk estimates apparently stronger in participants with lower eGFR.