van Rosendael AR, Narula J, Lin FY, et al. - Researchers sought to determine if the increasing density in calcified coronary plaque is correlated with risk for acute coronary syndrome (ACS). Researchers designed a multicenter case-control cohort study including individuals in ICONIC (Incident Coronary Syndromes Distinguished by CT), a nested case-control study of individuals drawn from the CONFIRM (Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter) registry, which included 13 study sites in 8 countries. They enrolled individuals who experienced core laboratory-verified ACS after baseline coronary computed tomography angiography (CCTA) and control individuals who did not experience ACS after baseline CCTA. The data demonstrated that 1K plaque identified by coronary CT angiography is correlated with a lower risk of future occurrence of ACS.