Alnæs D, et al. - The authors aimed at determining if brain dysconnectivity is a transdiagnostic phenotype in adolescence with increased susceptibility and symptoms of psychiatric disease. In this work, dimensional and heritable general cognitive and psychopathology factors were found to be correlated with specific patterns of white matter properties. Findings thereby suggested that in individuals with increased susceptibility and symptoms of psychiatric disorders, dysconnectivity was a transdiagnostic brain-based phenotype.