Lai Z, Chen J, Ding C, et al. - Via evaluating liver biopsies from 18 control candidates and 47 patients with nonalcoholic fatty liver disease (NAFLD), researchers assessed hepatic global DNA methylation and serum one-carbon metabolite concentrations and the possible relationships of these parameters with liver histology. According to findings, patients with NAFLD had lower hepatic levels of global DNA methylation and high concentrations of serum homocysteine correlated with NAFLD's histological severity. With increasing hepatic steatosis grade and disease progression, this level tended to rise.