Association of health status scores with cardiovascular and limb outcomes in patients with symptomatic peripheral artery disease: Insights from the EUCLID (Examining Use of Ticagrelor in Symptomatic Peripheral Artery Disease) trial
Journal of the American Heart Association Oct 19, 2020
Rymer JA, Mulder H, Smolderen KG, et al. - Since there exist limited data regarding health status tools in patients experiencing peripheral artery disease and cardiovascular and limb events, therefore, researchers examined the link between health status alterations and cardiovascular and limb events. By performing an analysis of the EUCLID (Examining Use of Ticagrelor in Symptomatic Peripheral Artery Disease) trial, they assessed the features of 13,801 patients by tertile of health status tool scores obtained in the trial (EuroQol 5‐Dimensions [EQ‐5D], EQ visual analog scale [VAS], and peripheral artery questionnaire). With EQ‐5D scores, VAS scores, and with peripheral artery questionnaire scores, there were 13,217 (95%), 13,533 (98%), and 4,431 (32%) patients, respectively. Decreased risk of subsequent major adverse cardiovascular events or lower‐extremity revascularization was observed in relation to improved EQ‐5D and VAS scores over 12 months. In clinical practice, a rare use of health status instruments was documented but these measures were found to be related to outcomes, including major adverse cardiovascular events, major adverse limb events, and lower‐extremity revascularization.
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