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Association of haemoglobin levels in the first trimester and at 26–30 weeks with fetal and neonatal outcomes: a secondary analysis of the Global Network for Women's and Children's Health's ASPIRIN Trial

BJOG: An International Journal of Obstetrics and Gynaecology Apr 20, 2021

Jessani S, Saleem S, Hoffman MK, et al. - Data from the ASPIRIN Trial were used to assess the correlation of various levels of haemoglobin measured from 6 +0 to 13 +6 weeks and 26 +0 to 30 +0 weeks of gestation in nulliparous women with pregnancy outcomes occurring at ≥ 20 weeks and at ≥ 26 weeks of gestation, respectively, in low‐ and middle‐income countries settings. The sample consisted of 11,976 pregnant women. Data reported that the mean haemoglobin levels at 6 +0–13 +6 weeks and at 26–30 weeks of gestation were 116 g/l (SD 17) and 107 g/l (SD 15), respectively. Lower and some higher haemoglobin concentrations are both associated with adverse fetal and neonatal outcomes at 6+0–13+6 weeks and at 26–30 weeks of gestation, though the association with low haemoglobin levels seems more consistent and generally stronger.

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