Yokota S, Tanaka H, Mochizuki Y, et al. - Researchers investigated patients with asymptomatic type 2 diabetes mellitus (T2DM; n = 100) with preserved left ventricular (LV) ejection fraction without coronary artery disease to determine the influence of glycemic variability (GV) on LV diastolic function in this patient population. Mitral inflow E and mitral e’ annular velocities (E/e’) defined LV diastolic function, and > 14 was determined as abnormal. The researchers noted that although age, sex-distribution, and hemoglobin A1c were similar between patients with high GV (≥ 35.9 mg/dL) and those with low GV, there was significantly higher E/e’ in those with high GV vs those with low GV. GV ≥ 35.9 mg/dL was identified as an independently related factor, as was age, of E/e’ > 14, per multivariate logistic regression analysis. Experts concluded that decreasing GV may be a potential novel treatment approach for the prevention of the development of heart failure with preserved ejection fraction (HFpEF) in patients with T2DM because HFpEF represents a syndrome induced by diverse agents.