Dai D, Sun Y, Liu C, et al. - Among patients with hemorrhagic stroke (n = 1,516), researchers examined the link between Glasgow Coma Scale (GCS) and total homocysteine (tHcy) levels, as well as assessed the possible effect modifiers. The mean (SD) of age, tHcy, and GCS levels were estimated to be 61.5 (11.3) years, 17.0 (10.3) μmol/L, and 13.9 (2.2), respectively. They found significantly lower transformed tHcy levels in participants with mild damage (GCS ≥ 13) vs those with severe damage (GCS < 9). Consistently, participants with mild damage (GCS ≥ 13) vs those with moderate to severe damage (GCS < 13) showed a significantly lower transformed tHcy levels. Among patients with hemorrhagic stroke, an inverse link between GCS level and tHcy concentration was evident; this was particularly seen in ever smokers or in those with higher systolic blood pressure or total cholesterol levels.