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Association of germline BRCA2 mutations with the risk of pediatric or adolescent non–Hodgkin lymphoma

JAMA Oncology Jul 31, 2019

Wang Z, Wilson CL, Armstrong GT, et al. - Researchers used whole-genome sequencing data and investigated the link between germline BRCA2 mutations and the risk for pediatric or adolescent lymphoma. From the St Jude Lifetime (SJLIFE) study and Childhood Cancer Survivor Study cohorts, they analyzed 794 additional survivors of lymphoma. By a previous report from SJLIFE study, BRCA2 (GenBank U43746 .1) was identified as the third most commonly mutated gene (14 occurrences) among 3,006 survivors of childhood cancer, with the highest number noted among lymphoma survivors.
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