Björnsson E, Thorleifsson G, Helgadóttir A, et al. - Researchers examined the influence of genetically predicted lipid levels on the extent of coronary atherosclerosis. For this genetic study, the Swedish Coronary Angiography and Angioplasty Registry and 2 registries of individuals who had undergone percutaneous coronary interventions and coronary artery bypass grafting were used to obtain data from January 1987 to December 2017 in Iceland. They calculated genetic scores for levels of non–high-density lipoprotein cholesterol (non–HDL-C), low-density lipoprotein cholesterol (LDL-C), HDL-C, and triglycerides, based on reported effect sizes of 345 independent, lipid-associated variants for all participants. Among more than 87,000 Icelandic adults, they assessed the genetic scores’ predictive ability for lipid levels. The analysis revealed a significant association of a genetic score for non–high-density lipoprotein cholesterol with the extent of coronary atherosclerosis, as estimated by coronary angiography or coronary calcium scanning in Icelandic adults. Persistence of the association was observed after accounting for low-density lipoprotein cholesterol. This indicates the possible significance of elevated non–high-density lipoprotein cholesterol as a better marker for atherogenic lipoproteins than low-density lipoprotein cholesterol.