Pao JB, et al. - The prognostic relevance of small non-coding RNA (sncRNA) single nucleotide polymorphism (SNP) for colorectal cancer was evaluated in this analysis. For the purpose of this investigation, the researchers comprehensively analyzed 31 common SNPs of sncRNAs, and evaluated the impact of these variants on survival in a cohort of 188 subjects with colorectal cancer. Three SNPs were significantly associated with survival in patients with colorectal cancer, after correction for multiple testing. The findings suggested that SNPs of sncRNAs could play a critical role in cancer progression. For colorectal cancer patients, hsa-miR-196a could be a valuable biomarker or therapeutic target.