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Association of fetal growth with general and specific mental health conditions

JAMA Feb 12, 2019

Pettersson E, et al. - In this register-based study conducted in Sweden, researchers analyzed 546,894 pairs of full siblings born between January 1, 1973, and December 31, 1998, to investigate the relation of fetal growth with general and specific mental health conditions, controlling for familial factors. They found a significant association of 9 outcomes with birth weight: depression, anxiety, posttraumatic stress disorder, bipolar disorder, alcohol abuse, drug use, violent crimes, attention-deficit/hyperactivity disorder, and autism. They noticed that only depression, obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, and autism were significantly associated with sibling pairs. Overall, they reported a correlation between retarded fetal growth and a small but significant inclined general factor of psychopathology and a moderate increase in a specific neurodevelopmental factor.
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